Cellulitis

Overview


Plain-Language Overview

Cellulitis is a common skin infection that affects the deeper layers of the skin and the underlying tissues. It usually occurs when bacteria enter through a break in the skin, causing redness, swelling, warmth, and pain in the affected area. The infection primarily involves the skin and soft tissues, often on the legs or arms. If untreated, it can spread rapidly and lead to serious complications such as abscess formation or bloodstream infection. People with weakened immune systems or chronic conditions like diabetes are at higher risk. The main health impact is localized inflammation that can impair normal skin function and cause systemic symptoms like fever.

Clinical Definition

Cellulitis is an acute, spreading infection of the dermis and subcutaneous tissues characterized by erythema, edema, warmth, and tenderness. It is most commonly caused by bacterial invasion, typically by Gram-positive cocci such as Staphylococcus aureus and Streptococcus pyogenes, entering through skin breaches. The infection leads to an inflammatory response with infiltration of neutrophils and release of cytokines. Clinically, it presents with localized pain, swelling, and systemic signs such as fever and leukocytosis. The condition is significant due to its potential for rapid progression, risk of complications like abscess or necrotizing fasciitis, and the need for prompt antimicrobial therapy. Diagnosis is primarily clinical, supported by history and physical exam findings.

Clinical Presentation


Diagnostic Workup


Pathophysiology


Treatments


Prevention


Outcome & Complications


Differential Diagnoses


Medical Disclaimer: The content on this site is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. If you think you may be experiencing a medical emergency, call 911 or your local emergency number immediately. Always consult a licensed healthcare professional with questions about a medical condition.

Artificial Intelligence Use: Portions of this site’s content were generated or assisted by AI and reviewed by Erik Romano, MD; however, errors or omissions may occur.

Analytics Disclosure: If you allow analytics cookies, Doctogenic uses Google Analytics, Microsoft Application Insights, and Microsoft Clarity to understand site usage, diagnose issues, review heatmaps and session replay recordings, and improve the service on pages where those tools are enabled. Clarity is not enabled on account, purchase, billing, checkout, Stripe-related, or admin pages. You can change this choice through Cookie preferences.

USMLE® is a registered trademark of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). Doctogenic and Roscoe & Romano are not affiliated with, sponsored by, or endorsed by the USMLE, FSMB, or NBME. Neither FSMB nor NBME has reviewed or approved this content. "USMLE Step 1" and "USMLE Step 2 CK" are used only to identify the relevant examinations.