Fibromyalgia

Overview


Plain-Language Overview

Fibromyalgia is a chronic condition that affects the musculoskeletal system, causing widespread pain and tenderness throughout the body. It primarily impacts the way the brain processes pain signals, leading to an increased sensitivity to pain. People with this condition often experience fatigue, sleep disturbances, and difficulty concentrating, sometimes called fibro fog. The symptoms can vary in intensity and may worsen with stress or physical activity. Although it does not cause damage to muscles or joints, the persistent pain and other symptoms can significantly affect daily life and overall well-being.

Clinical Definition

Fibromyalgia is a chronic disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep disturbances, and cognitive dysfunction. The core pathology involves abnormal central pain processing and central sensitization, leading to heightened pain perception without peripheral tissue damage. The exact cause is unknown but is thought to involve a combination of genetic predisposition, environmental triggers, and neurochemical imbalances affecting neurotransmitters such as serotonin and substance P. It is a functional pain syndrome with no identifiable inflammatory or structural abnormalities. The condition is clinically significant due to its impact on quality of life and its frequent association with psychiatric comorbidities such as anxiety and depression.

Clinical Presentation


Diagnostic Workup


Pathophysiology


Treatments


Prevention


Outcome & Complications


Differential Diagnoses


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