Heat Stroke

Overview


Plain-Language Overview

Heat stroke is a serious condition that happens when the body gets too hot and cannot cool down properly. It mainly affects the body's temperature regulation system, which controls how heat is lost through sweating and blood flow. When exposed to very high temperatures or intense physical activity in hot weather, the body’s core temperature can rise dangerously. This can cause damage to vital organs like the brain, heart, and kidneys. Symptoms often include a very high fever, confusion, headache, and sometimes loss of consciousness. Because it affects the brain and other organs, heat stroke is a medical emergency. Immediate attention is needed to prevent severe complications or death.

Clinical Definition

Heat stroke is a life-threatening condition characterized by a core body temperature exceeding 40°C (104°F) due to failure of the body's thermoregulatory mechanisms. It results from prolonged exposure to environmental heat or strenuous physical exertion in hot conditions, leading to impaired heat dissipation. The core pathology involves thermoregulatory failure, causing hyperthermia and subsequent multiorgan dysfunction, especially affecting the central nervous system. Clinically, it presents with central nervous system dysfunction such as delirium, seizures, or coma, along with anhidrosis or profuse sweating depending on the subtype. The condition can rapidly progress to rhabdomyolysis, coagulopathy, and acute kidney injury. Early recognition and aggressive management are critical to reduce morbidity and mortality.

Clinical Presentation


Diagnostic Workup


Pathophysiology


Treatments


Prevention


Outcome & Complications


Differential Diagnoses


Medical Disclaimer: The content on this site is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. If you think you may be experiencing a medical emergency, call 911 or your local emergency number immediately. Always consult a licensed healthcare professional with questions about a medical condition.

Artificial Intelligence Use: Portions of this site’s content were generated or assisted by AI and reviewed by Erik Romano, MD; however, errors or omissions may occur.

Analytics Disclosure: If you allow analytics cookies, Doctogenic uses Google Analytics, Microsoft Application Insights, and Microsoft Clarity to understand site usage, diagnose issues, review heatmaps and session replay recordings, and improve the service on pages where those tools are enabled. Clarity is not enabled on account, purchase, billing, checkout, Stripe-related, or admin pages. You can change this choice through Cookie preferences.

USMLE® is a registered trademark of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). Doctogenic and Roscoe & Romano are not affiliated with, sponsored by, or endorsed by the USMLE, FSMB, or NBME. Neither FSMB nor NBME has reviewed or approved this content. "USMLE Step 1" and "USMLE Step 2 CK" are used only to identify the relevant examinations.