Osteomyelitis

Overview


Plain-Language Overview

Osteomyelitis is an infection of the bone that can cause severe pain and swelling. It primarily affects the skeletal system and can lead to damage or destruction of the bone tissue. The infection usually occurs when bacteria or fungi enter the bone through the bloodstream, an open wound, or nearby infected tissue. Common symptoms include fever, localized bone pain, and redness or warmth over the affected area. If untreated, it can cause chronic problems such as persistent pain, bone deformity, or even spread of infection to other parts of the body. Early diagnosis and treatment are important to prevent long-term complications.

Clinical Definition

Osteomyelitis is a localized or diffuse infection of the bone and bone marrow characterized by inflammation and progressive bone destruction. It is most commonly caused by hematogenous spread of bacteria, especially Staphylococcus aureus, or by direct inoculation from trauma or surgery. The infection triggers an inflammatory response leading to necrosis of bone tissue and formation of sequestra (dead bone fragments). Clinically, it presents with localized bone pain, fever, and sometimes systemic signs of infection. Chronic osteomyelitis may develop if the infection persists, resulting in sinus tract formation and chronic draining wounds. The condition is significant due to its potential to cause permanent bone damage and systemic illness if not promptly managed.

Clinical Presentation


Diagnostic Workup


Pathophysiology


Treatments


Prevention


Outcome & Complications


Differential Diagnoses


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