Hemolytic Anemias
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Hemolytic Anemias conditions
Autoimmune Hemolytic AnemiaAutoimmune Hemolytic Anemia is characterized by antibody-mediated destruction of red blood cells, often diagnosed by a positive direct Coombs test.Drug-Induced Hemolytic AnemiaDrug-Induced Hemolytic Anemia is a condition where certain medications trigger immune-mediated destruction of red blood cells, causing anemia and elevated bilirubin.Extravascular HemolysisExtravascular hemolysis involves red blood cell destruction by macrophages in the spleen, often causing anemia with elevated unconjugated bilirubin and splenomegaly.G6PD DeficiencyG6PD deficiency is an X-linked enzyme disorder causing hemolytic anemia triggered by oxidative stress, commonly diagnosed by reduced NADPH production in red cells.Hemolytic Anemia Due to InfectionHemolytic anemia due to infection involves red blood cell destruction triggered by pathogens like malaria, causing anemia and jaundice through immune-mediated lysis.Hemolytic Disease of the Fetus and Newborn (ABO)Hemolytic Disease of the Fetus and Newborn ABO involves maternal anti-A or anti-B antibodies causing fetal red cell hemolysis and jaundice in newborns.Hemolytic Disease of the Fetus and Newborn (Rh)Hemolytic Disease of the Fetus and Newborn (Rh) involves maternal anti-Rh antibodies causing fetal red cell destruction and hemolytic anemia in affected newborns.Hereditary SpherocytosisHereditary Spherocytosis is a genetic hemolytic anemia caused by red blood cell membrane defects leading to spherocytes and increased osmotic fragility.Intravascular HemolysisIntravascular hemolysis involves destruction of red blood cells within blood vessels, causing hemoglobin release, anemia, hemoglobinuria, and elevated LDH levels.Macroangiopathic Hemolytic AnemiaMacroangiopathic hemolytic anemia is a hemolytic disorder caused by mechanical destruction of red blood cells, often linked to prosthetic heart valves or vascular pathology.Microangiopathic Hemolytic AnemiaMicroangiopathic Hemolytic Anemia is a disorder where red blood cells are damaged in small blood vessels, causing hemolysis and schistocytes on blood smear.Pyruvate Kinase DeficiencyPyruvate Kinase Deficiency is a hereditary hemolytic anemia caused by impaired glycolysis in red blood cells leading to chronic hemolysis and jaundice.Thrombotic Thrombocytopenic Purpura (TTP)Thrombotic Thrombocytopenic Purpura (TTP) is a rare blood disorder causing microangiopathic hemolytic anemia and thrombocytopenia due to ADAMTS13 deficiency.