Systemic Autoimmunity and Connective Tissue
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Systemic Autoimmunity and Connective Tissue conditions
Antiphospholipid SyndromeAntiphospholipid Syndrome is an autoimmune disorder causing hypercoagulability and recurrent thrombosis due to antibodies against phospholipid-binding proteins.CREST syndromeCREST syndrome is a limited form of systemic sclerosis characterized by calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia.DermatomyositisDermatomyositis is an inflammatory myopathy characterized by proximal muscle weakness and a distinctive heliotrope rash, often associated with elevated muscle enzymes.Diffuse sclerodermaDiffuse scleroderma is a systemic autoimmune disease causing widespread skin thickening and early internal organ fibrosis, often with anti-Scl-70 antibodies.IgG4-related DiseaseIgG4-related disease is a fibroinflammatory condition marked by elevated IgG4 plasma cells causing tumefactive lesions and organ dysfunction.Mixed Connective Tissue Disease (MCTD)Mixed Connective Tissue Disease (MCTD) is an autoimmune overlap syndrome marked by anti-U1 RNP antibodies and features of lupus, scleroderma, and polymyositis.PolymyositisPolymyositis is an inflammatory muscle disease causing progressive weakness, primarily affecting proximal muscles with elevated muscle enzymes and characteristic biopsy findings.Raynaud diseaseRaynaud disease is a vascular disorder causing episodic vasospasm of the fingers and toes, leading to color changes, numbness, and cold sensitivity.Raynaud syndromeRaynaud syndrome causes episodic vasospasm of extremity arteries triggered by cold or stress, leading to color changes and numbness in fingers and toes.Sjögren SyndromeSjögren Syndrome is an autoimmune disorder causing dry eyes and dry mouth due to lymphocytic infiltration of exocrine glands, often with positive anti-Ro and anti-La antibodies.Systemic Lupus Erythematosus (SLE)Systemic Lupus Erythematosus (SLE) is a multisystem autoimmune disease characterized by antinuclear antibodies and diverse clinical manifestations including malar rash.