Cannabis/cannabinoids withdrawal

Cannabis/cannabinoids withdrawal occurs when a person who regularly uses cannabis suddenly stops or reduces their intake. This condition primarily affects the nervous system, leading to a range of physical and psychological symptoms. Common signs include irritability, anxiety, sleep disturbances, and decreased appetite. These symptoms result from the brain's adjustment to the absence of cannabinoids, which normally interact with the endocannabinoid system to regulate mood and appetite. Withdrawal symptoms typically begin within a few days after cessation and can last up to two weeks. The condition can significantly impact daily functioning and well-being during this period.

Cannabis/cannabinoids withdrawal is a clinically recognized syndrome characterized by a constellation of symptoms that arise after abrupt cessation or reduction of prolonged and heavy cannabis use. The core pathology involves dysregulation of the endocannabinoid system, particularly decreased stimulation of CB1 receptors in the central nervous system. This leads to neurochemical imbalances affecting mood, sleep, and appetite regulation. The syndrome typically manifests within 24 to 72 hours after stopping cannabis and peaks within the first week. Major clinical features include irritability, anxiety, insomnia, decreased appetite, and restlessness. The condition is significant because it can contribute to relapse in individuals attempting to quit cannabis and may require supportive management.