Separation anxiety disorder

Overview


Plain-Language Overview

Separation anxiety disorder is a condition that affects the brain and emotions, causing intense fear or distress when a person is away from someone they feel attached to, usually a parent or caregiver. It mainly impacts children but can also occur in adults. This disorder involves the nervous system and emotional regulation, leading to symptoms like excessive worry about harm coming to loved ones or being lost. People with this condition may experience physical symptoms such as headaches or stomachaches when separated. The disorder can interfere with daily activities like school or work and affect social relationships. Understanding this condition helps explain why some individuals have strong emotional reactions to separation.

Clinical Definition

Separation anxiety disorder is a psychiatric condition characterized by excessive and developmentally inappropriate fear or anxiety concerning separation from attachment figures. It involves dysregulation of the limbic system and hypothalamic-pituitary-adrenal axis, leading to heightened stress responses. The disorder typically arises from a combination of genetic predisposition, environmental stressors, and early attachment disruptions. Clinically, it presents with persistent worry about losing major attachment figures, reluctance or refusal to be alone, and somatic complaints during separation. It is significant because it can impair social, academic, and occupational functioning and increase risk for other anxiety disorders. Diagnosis requires symptoms lasting at least 4 weeks in children and 6 months in adults, with marked distress or impairment.

Inciting Event

Locked content

Latency Period

Locked content

Diagnostic Delay

Locked content

Clinical Presentation


Signs & Symptoms

Locked content

History of Present Illness

Locked content

Past Medical History

Locked content

Family History

Locked content

Physical Exam Findings

Locked content

Diagnostic Workup


Diagnostic Criteria

Locked content

Pathophysiology


Key Mechanisms

Locked content

Organs

Locked content

Tissues

Locked content

Cells

Locked content

Chemical Mediators

Locked content

Treatments


Pharmacological Treatments

Locked content

Non-pharmacological Treatments

Locked content

Prevention


Pharmacological Prevention

Locked content

Non-pharmacological Prevention

Locked content

Outcome & Complications


Complications

Locked content

Short-term Sequelae

Locked content

Long-term Sequelae

Locked content

Differential Diagnoses


Differentials

Locked content

Medical Disclaimer: The content on this site is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. If you think you may be experiencing a medical emergency, call 911 or your local emergency number immediately. Always consult a licensed healthcare professional with questions about a medical condition.

Artificial Intelligence Use: Portions of this site’s content were generated or assisted by AI and reviewed by Erik Romano, MD; however, errors or omissions may occur.

USMLE® is a registered trademark of the Federation of State Medical Boards (FSMB) and the National Board of Medical Examiners (NBME). Doctogenic and Roscoe & Romano are not affiliated with, sponsored by, or endorsed by the USMLE, FSMB, or NBME. Neither FSMB nor NBME has reviewed or approved this content. "USMLE Step 1" and "USMLE Step 2 CK" are used only to identify the relevant examinations.