Myocarditis (Autoimmune)
Overview
Plain-Language Overview
Myocarditis (Autoimmune) is a condition where the body's immune system mistakenly attacks the heart muscle, causing inflammation. This affects the heart, which is responsible for pumping blood throughout the body. The inflammation can weaken the heart muscle, leading to symptoms like chest pain, shortness of breath, and fatigue. It may also cause irregular heartbeats or heart failure if severe. The condition can develop suddenly or gradually and may require medical evaluation to determine the cause and severity.
Clinical Definition
Myocarditis (Autoimmune) is characterized by inflammatory infiltration of the myocardium due to an aberrant immune response against cardiac antigens. It is a subtype of myocarditis where the immune system, often triggered by molecular mimicry or loss of self-tolerance, attacks the heart muscle without an infectious cause. This leads to myocyte necrosis, interstitial edema, and impaired cardiac function. Commonly associated with systemic autoimmune diseases such as systemic lupus erythematosus or giant cell myocarditis, it can cause arrhythmias, heart failure, and sudden cardiac death. Diagnosis requires exclusion of infectious etiologies and recognition of immune-mediated injury. The condition is clinically significant due to its potential to cause acute or chronic cardiac dysfunction.
Inciting Event
Locked content
Latency Period
Locked content
Diagnostic Delay
Locked content
Clinical Presentation
Signs & Symptoms
Locked content
History of Present Illness
Locked content
Past Medical History
Locked content
Family History
Locked content
Physical Exam Findings
Locked content
Diagnostic Workup
Diagnostic Criteria
Locked content
Pathophysiology
Key Mechanisms
Locked content
Organs
Locked content
Tissues
Locked content
Cells
Locked content
Chemical Mediators
Locked content
Treatments
Pharmacological Treatments
Locked content
Non-pharmacological Treatments
Locked content
Prevention
Pharmacological Prevention
Locked content
Non-pharmacological Prevention
Locked content
Outcome & Complications
Complications
Locked content
Short-term Sequelae
Locked content
Long-term Sequelae
Locked content
Differential Diagnoses
Differentials
Locked content