Septic Arthritis

Overview


Plain-Language Overview

Septic arthritis is a serious joint infection that affects the body's musculoskeletal system. It occurs when bacteria or other germs enter a joint, causing intense pain, swelling, and redness. The infection can rapidly damage the joint, leading to loss of movement and long-term problems if not treated quickly. The most commonly affected joints are the knee, hip, and shoulder. This condition mainly impacts the joint's ability to function properly and can cause fever and general illness. Early recognition and treatment are crucial to prevent permanent joint damage.

Clinical Definition

Septic arthritis is an acute infection of a synovial joint characterized by the invasion of the joint space by pathogenic microorganisms, most commonly Staphylococcus aureus. The infection leads to an intense inflammatory response with accumulation of purulent synovial fluid, causing rapid joint destruction if untreated. It typically presents with monoarticular joint pain, swelling, erythema, and decreased range of motion, often accompanied by systemic signs such as fever. Risk factors include preexisting joint disease, immunosuppression, and recent joint surgery or injection. The condition is a medical emergency due to the risk of irreversible cartilage damage and systemic sepsis.

Inciting Event

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Latency Period

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Diagnostic Delay

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Clinical Presentation


Signs & Symptoms

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History of Present Illness

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Past Medical History

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Family History

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Physical Exam Findings

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Diagnostic Workup


Diagnostic Criteria

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Pathophysiology


Key Mechanisms

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Organs

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Tissues

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Cells

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Chemical Mediators

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Treatments


Pharmacological Treatments

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Non-pharmacological Treatments

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Prevention


Pharmacological Prevention

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Non-pharmacological Prevention

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Outcome & Complications


Complications

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Short-term Sequelae

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Long-term Sequelae

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Differential Diagnoses


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Artificial Intelligence Use: Portions of this site’s content were generated or assisted by AI and reviewed by Erik Romano, MD; however, errors or omissions may occur.

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