Peyronie Disease

Peyronie Disease is a condition that affects the penis, specifically the connective tissue inside it. It causes the development of fibrous scar tissue that leads to abnormal curvature or bending during an erection. This can result in pain, difficulty with sexual intercourse, and sometimes erectile dysfunction. The disease primarily impacts the health and function of the male reproductive system. The severity of symptoms varies, with some men experiencing mild discomfort and others having significant deformity. The condition often develops gradually and can affect emotional well-being due to its impact on sexual activity.

Peyronie Disease is characterized by the formation of fibroplastic plaques within the tunica albuginea of the penis, leading to penile curvature, deformity, and sometimes pain during erection. The underlying mechanism involves abnormal wound healing and excessive collagen deposition following microvascular injury or trauma to the penile tissue. This results in localized fibrosis and loss of elasticity. The disease is typically acquired and can cause significant sexual dysfunction and psychological distress. It is more common in middle-aged men and may be associated with other fibrotic disorders such as Dupuytren contracture. The condition can be classified into acute and chronic phases based on symptom duration and plaque stability.